Amoxicillin

Please note: This is for information only.

Refer to local guidelines for treatment recommendations

 


 

  • A β-Lactam penicillin antibiotic
  • Bactericidal
  • Some Gram negative activity
  • Reasonable oral absorption (oral preparation Amoxicillin)
  • Usual adult dose IV Amoxicillin 500mg-1g tds (higher doses: 2g 4 hourly, are used for treatment of endocarditis), PO Amoxicillin 500mg tds
  • Reduce dose in moderate to severe renal impairment
  • Moderate risk of Clostridium difficile antibiotic-associated diarrhoea if prescribed for elderly inpatients.

Main indications

  • Upper respiratory tract infection e.g. otitis media, sinusitis
  • Community Acquired Pneumonia
  • Acute Bronchitis
  • Cellulitis
  • Peritonitis and Diverticulitis
  • Endocarditis prophylaxis
  • Alternative for UTI if known sensitive organism
  • Active against most strains of:
  • Streptococcus pneumoniae
  • Haemophilus influenzae (except in patients with COPD as resistance more likely due to repeat courses of antibiotics)
  • Beta haemolytic streptococci
  • Enterococcus faecalis

Not active against most strains of:

  • Staphylococcus aureus; Staphylococcus epidermidis
  • Atypical bacteria
  • Anaerobes from GI tract eg Bacteroides fragilis
  • Pseudomonas
  • Klebsiella spp
  • Enterococcus faecium
  • Variable activity against Escherichia coli - 50% strains are resistant.