Benzylpenicillin (Penicillin G)
Please note: This is for information only.
Refer to local guidelines for treatment recommendations
- A penicillin
- Usual adult dose 1.2 g IV QDS increasing to 1.2 g 4-hourly for streptococcal endocarditis or 2.4 g QDS for meningococcal sepsis
- Dosage reduction necessary if renal impairment
- Available IV only.
- Crosses CSF only if meninges inflamed.
- Community acquired pneumonia
- Streptococcal endocarditis
- Other serious streptococcal infections
Active against most strains of:
- Streptococci (Group A, B, C, G, viridans, pneumoniae, milleri)
- Neisseria meningitidis
- Neisseria gonorrhoea - although many strains have low level resistance
- Clostridium difficile
- Clostridium perfringens
Not active against most strains of:
- Haemophilus influenzae
- Bacteroides fragilis