Cefotaxime

Please note: This is for information only.

Refer to local guidelines for treatment recommendations

 


 

  • A 3rd generation cephalosporin antibiotic (similar to ceftriaxone)
  • Bactericidal
  • Injectable form only available. Can give IV or IM.
  • Crosses blood brain barrier ONLY if meninges inflamed.
  • High risk of Clostridium difficile antibiotic-associated diarrhoea if prescribed for elderly inpatients.
  • Not to be used in patients with a serious penicillin allergy (e.g. anaphylaxis).

Main indications:

  • Only used for neonates – see Neonatal specialist guidelines
  • Ceftriaxone is the preferred 3rd generation cephalosporin for adults

Active against most strains of:

  • Staphylococcus aureus (NOT MRSA)
  • Streptococci
  • Escherichia coli
  • Klebsiella sp
  • Proteus sp
  • Enterobacter sp
  • Neisseria meningitidis
  • Neisseria gonorrhoea

Not active against most strains of:

  • MRSA
  • Enterococcus
  • Bacteroides
  • Pseudomonas
  • Listeria monocytogenes