Please note: This is for information only.

Refer to local guidelines for treatment recommendations



  • A 1st generation cephalosporin antibiotic.
  • Bactericidal
  • Usual adult dose: up to 2g per day in 2-4 divided doses.
  • Good activity against Gram positive organisms.
  • Reasonable bioavailability when given orally.
  • Adjust dose if severe renal impairment
  • IV and oral preparations available, though IV use restricted to surgical prophylaxis.
  • Unaffected by the degrading effects of penicillinase
  • High risk of Clostridium difficile antibiotic-associated diarrhoea if prescribed for elderly in-patients.
  • Not to be used in patients with a serious penicillin allergy (e.g. anaphylaxis).

Main indications

  • Orthopaedic surgical prophylaxis
  • Alternative treatment for urinary tract infections
  • Alternative agent to flucloxacillin if penicillin allergy. CARE: 10% chance of cross allergy if anaphylaxis to penicillins.

Active against most strains of:

  • Staphylococcus aureus (NOT MRSA)
  • Haemolytic streptococci
  • Streptococcus pneumoniae
  • Escherichia coli (but only for UTI)

Not active against most strains of:

  • MRSA
  • Haemophilus influenzae
  • Enterococcus
  • Anaerobes
  • Pseudomonas