Please note: This is for information only.
Refer to local guidelines for treatment recommendations
- A 1st generation cephalosporin antibiotic.
- Usual adult dose: up to 2g per day in 2-4 divided doses.
- Good activity against Gram positive organisms.
- Reasonable bioavailability when given orally.
- Adjust dose if severe renal impairment
- IV and oral preparations available, though IV use restricted to surgical prophylaxis.
- Unaffected by the degrading effects of penicillinase
- High risk of Clostridium difficile antibiotic-associated diarrhoea if prescribed for elderly in-patients.
- Not to be used in patients with a serious penicillin allergy (e.g. anaphylaxis).
- Orthopaedic surgical prophylaxis
- Alternative treatment for urinary tract infections
- Alternative agent to flucloxacillin if penicillin allergy. CARE: 10% chance of cross allergy if anaphylaxis to penicillins.
Active against most strains of:
- Staphylococcus aureus (NOT MRSA)
- Haemolytic streptococci
- Streptococcus pneumoniae
- Escherichia coli (but only for UTI)
Not active against most strains of:
- Haemophilus influenzae