Ceftazidime

Please note: This is for information only.

Refer to local guidelines for treatment recommendations

 


 

  • A 3rd generation cephalosporin antibiotic
  • Bactericidal
  • Resistant to most ß-lactamases
  • Good anti-pseudomonal activity
  • Usual adult dose: 1g tds
  • Dosage adjustment needed if renal impairment
  • Can be given IV or IM; no oral preparation available
  • Penetrates well into bile, bone, heart and synovial, pleural and peritoneal fluids. Only penetrates into CSF in presence of inflammation.
  • High risk of Clostridium difficile antibiotic-associated diarrhoea if prescribed for elderly in-patients.
  • Not to be used in patients with a serious penicillin allergy (e.g. anaphylaxis).

Main indications:

  • Likely pseudomonal infections
  • Active against most strains of:
  • Haemophilus influenzae
  • Escherichia coli
  • Klebsiella
  • Other coliforms
  • Pseudomonas aeruginosa
  • Streptococci

Not active against most strains of:

  • Staphylococcus aureus
  • Enterococcus
  • Listeria monocytogenes
  • Anaerobes