Please note: This is for information only.
Refer to local guidelines for treatment recommendations
- A 3rd generation cephalosporin antibiotic
- Resistant to most ß-lactamases
- Good anti-pseudomonal activity
- Usual adult dose: 1g tds
- Dosage adjustment needed if renal impairment
- Can be given IV or IM; no oral preparation available
- Penetrates well into bile, bone, heart and synovial, pleural and peritoneal fluids. Only penetrates into CSF in presence of inflammation.
- High risk of Clostridium difficile antibiotic-associated diarrhoea if prescribed for elderly in-patients.
- Not to be used in patients with a serious penicillin allergy (e.g. anaphylaxis).
- Likely pseudomonal infections
- Active against most strains of:
- Haemophilus influenzae
- Escherichia coli
- Other coliforms
- Pseudomonas aeruginosa
Not active against most strains of:
- Staphylococcus aureus
- Listeria monocytogenes