Ceftriaxone

Please note: This is for information only.

Refer to local guidelines for treatment recommendations

 


 

  • A 3rd generation cephalosporin antibiotic
  • Bactericidal
  • Usual adult dose: 1g daily. Use 2g bd for adult meningitis.
  • No dose reduction necessary if renal impairment. Maximum dose 2g/day if severe impairment.
  • Injectable form only available. Can be given IV or IM.
  • Penetrates into cerebrospinal fluid.
  • High risk of Clostridium difficile antibiotic-associated diarrhoea if prescribed for elderly inpatients.
  • Not to be used in patients with a serious penicillin allergy (e.g. anaphylaxis).

Main indications:

  • Meningitis or intracranial sepsis
  • Microbiology advice.
  • Uncomplicated gonococcal infection

Active against most strains of:

  • Streptococcus pneumoniae
  • Haemolytic streptococci
  • Neiserria gonnorrhoea, Neisseria meningitidis
  • Moraxella
  • Escherichia coli
  • Other coliforms

Not active against most strains of:

  • MRSA
  • Enterococcus
  • Clostridium difficile
  • Pseudomonas aeruginosa
  • Listeria monocytogenes