Please note: This is for information only.

Refer to local guidelines for treatment recommendations



  • A second generation cephalosporin
  • Increased Gram negative activity compared to the first generation cephalosporins
  • Usual adult dose: 750mg - 1.5g tds IV
  • Oral preparation restricted use
  • Dose reduction necessary in moderate to severe renal impairment
  • Good tissue penetration but poor CSF penetration
  • High risk of Clostridium difficile antibiotic-associated diarrhoea if prescribed for elderly in-patients.
  • Not to be used in patients with a serious penicillin allergy (e.g. anaphylaxis).

Main indications

  • Restricted

Active against most strains of:

  • Streptococcus pneumoniae
  • Haemophilus.influenzae
  • Moraxella catarrhalis
  • Coliforms (E.coli, Klebsiella, Proteus, Enterobacter)
  • Staphylococcus aureus (not MRSA)
  • b haemolytic streptococci

Not active against most strains of:

  • MRSA
  • Enterococcus
  • Anaerobes
  • Pseudomonas