Chloramphenicol

Please note: This is for information only.

Refer to local guidelines for treatment recommendations

 


 

  • Bacteriostatic for most organisms; bactericidal to H influenzae.
  • Usual adult dose: 50mg/kg/day in 4 divided doses
  • Can be given IV, IM or orally.
  • Absorption unpredictable following IM administration.
  • Renally excreted therefore reduce dose if renal impairment.
  • Causes serious blood dyscrasias which may be fatal therefore use restricted.
  • Penetrates well into CSF and tissue.
  •  

Main indications:

  • Microbiology or infectious diseases advice only (IV and PO formulations).
  • Used topically for empirical treatment of eye infections.

Active against most strains of:

  • H influenzae
  • Listeria
  • Streptococus pneumoniae
  • Salmonella spp including S typhi
  • Anaerobes

Not active against most strains of:

  • Coliforms
  • Pseudomonas