Ciprofloxacin

Please note: This is for information only.

Refer to local guidelines for treatment recommendations


 

 

 

  • A quinolone antibiotic, similar to levofloxacin
  • Usual adult dose: 250mg – 500mg bd orally, increased to 750mg bd for severe infections/Pseudomonas.
  • Good bioavailability when given orally
  • IV preparation is very expensive and the licensed dose is lower than the oral regime. IV ciprofloxacin is a restricted antibiotic.
  • Dosage reduction may be necessary in renal impairment.
  • Use with caution in patients with epilepsy.
  • Contra-indicated in pregnancy.
  • High risk of Clostridium difficile antibiotic-associated diarrhoea if prescribed for elderly inpatients.

Main indications: Oral

  • UTI
  • Biliary Sepsis
  • Diabetic Ulcers
  • Osteomyelitis (high risk)
  • Oncology and haematology specialist guidelines

Main indications: IV

  • Microbiology advice only – restricted agent
  • Active against most strains of:
  • Staphylococcus aureus (not MRSA)
  • Neisseria gonorrhoea*
  • Haemophilus influenzae
  • Moraxella catarrhalis
  • Escherichia coli
  • Klebsiella sp
  • Pseudomonas
  • Legionella
  • Salmonella
  • Campylobacter

Not active against most strains of:

  • MRSA
  • Enterococci
  • Anaerobes
  • Partial activity against Strep pneumoniae
  • *currently the resistance rates are ~20% therefore not suitable for first line empirical treatment of gonorrhoea.