Clarithromycin

Please note: This is for information only.

Refer to local guidelines for treatment recommendations


 

 

 

  • A macrolide antibiotic, semi-synthetic derivative of erythromycin.
  • Usual adult dose: 500mg twelve hourly – IV and oral.
  • Dosage adjustment needed if renal impairment.
  • Injection to be given by IV infusion only.
  • Moderate risk of Clostridium difficile antibiotic-associated diarrhoea if prescribed for elderly inpatients.

Main indications:

  • Severe community acquired pneumonia
  • Legionnaires’ disease
  • H pylori eradication (as part of triple therapy in Helimet® and Heliclear®)

 

Active against most strains of:

  • Staphylococcus aureus
  • Streptococcus
  • Haemophilus influenzae
  • Moraxella
  • Legionella pneumophila
  • Chlamydia
  • Helicobacter pylori
  • Mycoplasma pneumonia

Not active against most strains of:

  • Enterococcus
  • Escherichia coli,
  • Klebsiella
  • Pseudomonas