Please note: This is for information only.
Refer to local guidelines for treatment recommendations
- Large Gram positive anaerobes that forms spores.
Main Clinical Infections:
- Gas gangrene, a complication of wound infection.
- Rapidly spreading oedema, myositis, tissue necrosis and gas production resulting in crepitus of adjacent tissues and profound toxaemia.
- Food Poisoning - from contaminated undercooked meat.
- C. perfringens colitis
- Similar to C. difficile colitis.
- Affects elderly patients on antibiotics
- Treatment of Gas gangrene:
- Surgical debridement of wound necessary.
- Hyperbaric oxygen may be useful
Usually sensitive to:
- Meropenem / Imipenem
Usually resistant to:
- Quinolones (levofloxacin, ciprofloxacin)
- Aminoglycosides (gentamicin, tobramycin, amikacin)