Clostridium perfringens

Please note: This is for information only.

Refer to local guidelines for treatment recommendations



  • Large Gram positive anaerobes that forms spores.

Main Clinical Infections:

  • Gas gangrene, a complication of wound infection.
  • Rapidly spreading oedema, myositis, tissue necrosis and gas production resulting in crepitus of adjacent tissues and profound toxaemia.
  • Food Poisoning - from contaminated undercooked meat.
  • C. perfringens colitis
  • Similar to C. difficile colitis.
  • Affects elderly patients on antibiotics
  • Treatment of Gas gangrene:
  • Surgical debridement of wound necessary.
  • Hyperbaric oxygen may be useful

Usually sensitive to:

  • Penicillins
  • Cefuroxime
  • Co-amoxiclav
  • Piptazobactam
  • Vancomycin
  • Metronidazole
  • Clindamycin
  • Meropenem / Imipenem

Usually resistant to:

  • Quinolones (levofloxacin, ciprofloxacin)
  • Aminoglycosides (gentamicin, tobramycin, amikacin)