Please note: This is for information only.

Refer to local guidelines for treatment recommendations.


  • A macrolide antibiotic similar to clarithromycin
  • Usual adult dose
  • Oral: 250-500mg qds (up to 1g qds in severe infections)
  • IV: Not used at GHNHSFT; clarithromycin is the preferred macrolide for IV use.
  • No dosage reduction necessary if renal impairment.
  • Coated tablets are needed to aid oral absorption by protecting from gastric acid.
  • Oral administration often results in gastro-intestinal disturbance.
  • IV infusions invariably produce thrombophlebitis.
  • Moderate risk of C difficile associated diarrhoea if given to elderly patients.

Main Indications

  • As an alternative to Penicillins for Penicillin-allergic patients
  • Whooping cough
  • Campylobacter enteritis
  • Active against most strains of:
  • Staphylococcus aureus (not MRSA)
  • Group A Streptococci
  • Streptococcus pneumoniae
  • Group B streptococci
  • Pathogens causing atypical pneumonia (Chlamydia pneumoniae, Legionella pneumoniae, Mycoplasma pneumoniae, Bordetella pertussis)
  • Moraxella catarrhalis
  • Chlamydia trachomatis
  • Campylobacter spp
  • Helicobacter pylori

Not active against most strains of:

  • MRSA
  • Enterococci
  • Anaerobes
  • Haemophilus influenzae