Flucloxacillin

Please note: This is for information only.

Refer to local guidelines for treatment recommendations


  • A penicillinase resistant penicillin
  • Excellent fasting oral availability (>90%); absorption reduced by food therefore take on an empty stomach.
  • Excellent tissue penetration
  • Usual adult oral dose 500mg – 1g qds
  • For severe infections, 2g qds IV
  • Dose reduction maybe necessary in severe renal failure

Main indications

  • 1st line antibiotic for all methicillin susceptible S. aureus (MSSA) infections (more efficacious than vancomycin against MSSA)
  • Empirical single agent treatment of wound infections and cellulitis where MRSA is NOT suspected

Active against most strains of:

  • Methicillin sensitive Staphylococcus aureus (i.e. NOT MRSA)
  • ß- haemolytic streptococci

Not active against most strains of:

  • MRSA
  • Most coagulase negative staphylococci
  • Enterococci
  • Coliforms
  • Pseudomonas
  • Anaerobes