Gentamicin

Please note: This is for information only.

Refer to local guidelines for treatment recommendations.


  • An aminoglycoside antibiotic.
  • Bactericidal.

 

2 dosing options:

  1. Once-daily Gentamicin Protocol 
  2. Conventional dosing (tds or bd) – only if once daily gentamicin not appropriate

 

  • Monitor levels – see TDM guide for recommendations.
  • As with all aminoglycosides, potentially nephrotoxic and ototoxic.

Contraindications:

  • Do not use in myeloma patients
  • Myasthenia gravis

Main indications:

  • Serious abdominal infections
  • Pelvic inflammatory disease
  • Serious infections of the urinary tract, including pyelonephritis
  • Endocarditis
  • Haematology, oncology, renal and neonatal specialist guidelines
  • Surgical prophylaxis
  • Active against most strains of:
  • Staphylococcus aureus – including MRSA
  • Escherichia coli
  • Klebsiella and other coliforms
  • Pseudomonas aeruginosa

Not active against most strains of:

  • Streptococci*
  • Enterococcus*
  • Streptococcus pneumoniae
  • Haemophilus influenzae

* Streptococci and enterococci are intrinsically resistant but gentamicin may act synergistically when used with cell wall active agents eg: penicillins or glycopeptides.