Please note: This is for information only.

Refer to local guidelines for treatment recommendations.

  • A ß-lactam antibiotic: carbapenem, similar to imipenem.
  • Bactericidal
  • Usual adult dose: 500mg – 1g tds IV
  • Preferred carbapenem if renal impairment. Dosage reduction necessary.
  • Very broad spectrum predisposes to candida and other multi-resistant organisms.
  • No oral preparation.
  • Penetrates into most tissues and fluids including cerebrospinal fluid.
  • Less likely to cause neurotoxicity (fitting) than imipenem.

Main indications:

  • Microbiology advice – restricted agent.

Active against most strains of:

  • Staphylococcus aureus (not MRSA)
  • Haemolytic streptococci
  • Streptococcus pneumoniae
  • Enterococcus faecalis (amoxicillin-sensitive)
  • Listeria monocytogenes
  • Neisseira meningitidis
  • Haemophilus influenzae
  • Escherichia coli
  • Klebsiella spp
  • Other Coliforms
  • Pseudomonas aeruginosa
  • Anaerobes

Not active against most strains of:

  • MRSA
  • Staphylococcus epidermidis
  • Enterococcus faecium (amoxicillin-resistant)
  • Candida and other fungal pathogens