Sodium fusidate (fusidic acid)

Please note: This is for information only.

Refer to local guidelines for treatment recommendations.


  • Bactericidal
  • Usual adult dose: 250mg – 500mg bd or tds
  • Excreted in bile therefore no need to reduce dose if renal impairment.
  • Monitor LFTs during therapy
  • Mostly used with another anti-staphylococcal agent to prevent resistance.
  • Penetrates well into bone and tissue – including necrotic tissue
  • Resistance develops quickly if used as monotherapy for systemic infections.
  • Topical treatment also available for conjunctivitis and minor skin sepsis.*

Main indications:

  • Adjunctive therapy for complicated staphylococcal infections
  • Active against most strains of:
  • Staphylococcus aureus – including MRSA*

Not active against most strains of:

  • Coliforms
  • Pseudomonas
  • Anaerobes

*Many “impetigo” strains of S aureus are now fusidic acid resistant.