Tazocin = piperacillin + tazobactam (Piptazobactam)

Please note: This is for information only.

Refer to local guidelines for treatment recommendations 


Important: Generic piperacillin/tazobactam and Tazocin® have different compatibilities with other medicines. Click here for specific information.

Piperacillin

  • An anti-pseudomonal penicillin.

Tazobactam

  • Inhibits ß-lactamases and thus enhances and extends the spectrum of activity of piperacillin

Tazocin:

  • The combination is bactericidal.
  • Usual adult dose: 4.5g iv 8 hourly.
  • No oral preparation.
  • Renally excreted therefore dosage adjustment necessary if renal impairment.

Main indications:

  • Microbiology advice – restricted agent
  • Pseudomonal infections
  • Aspiration Pneumonia
  • Hospital Acquired Pneumonia
  • Biliary Sepsis
  • Diabetic Ulcer

Active against most strains of:

  • Staphylococcus aureus (not MRSA)
  • Haemolytic streptococci
  • Enterococcus faecalis (amoxicillin-sensitive)
  • Streptococcus pneumoniae
  • Haemophilus influenzae
  • Escheriachia coli
  • Klebsiella spp
  • Coliforms
  • Pseudomonas aeruginosa

Not active against most strains of:

  • MRSA
  • Staphylococcus epidermidis
  • Enterococcus faecium (amoxicillin-resistant)