Differences between generic piperacillin/tazobactam & Tazocin® (piperacillin/tazobactam)
Generic piperacillin/tazobactam and Tazocin® have different compatibilities with other medicines.
All prescribers and staff administering intravenous drugs should be aware of the following:
Reconstitution and administration information:
The generic product is incompatible with compound sodium lactate (Hartmann’s) solution. Add 20ml of water for injection or sodium chloride 0.9% to a vial containing generic piperacillin/tazobactam 4g/0.5g or (10ml for a 2g/0.25g vial). Administer as a slow intravenous injection over 3 to 5 minutes. If preferred, the dose can be further diluted into a convenient volume (eg.100ml) for infusion using glucose 5% or sodium chloride 0.9% only and given over 20 – 40 minutes.
Co-administration with other antibiotics:
Piperacillin/tazobactam and an aminoglycoside antibiotic (gentamicin, tobramycin, amikacin) are commonly prescribed in combination to treat serious infections. Due to incompatibility, generic piperacillin/tazobactam must not be mixed with an aminoglycoside during administration because aminoglycosides are substantially inactivated by generic piperacillin/tazobactam.
Administration one after the other down the same line is acceptable as long as the line is flushed between each drug with a compatible fluid. Similarly, simultaneous administration down separate lumens of a multilumen venous access device is acceptable. Administration via a Y-site is not acceptable as there will be mixing of the drugs within the line.
Generic piperacillin/tazobactam must not be reconstituted or diluted in Hartmann’s (lactated Ringers) solution
Generic piperacillin/tazobactam must not be mixed or co-administered with any aminoglycoside (i.e. gentamicin, tobramycin, amikacin)