Please note: This is for information only.

Refer to local guidelines for treatment recommendations

  • A glycopeptide antibiotic.
  • Doses based on actual body weight and indication.
  • Loading doses are given every 12 hours for 4 - 5 doses depending on indication.
  • Maintenance doses are given ONCE DAILY starting 24 hours after the last loading dose.
  • Take a pre-dose level on the 5th day and weekly thereafter.
  • Dose adjustment needed in renal impairment (CrCl less than or equal to 30ml/min). (Click here)



Respiratory, Cellulitis, Neutropenic Sepsis
and Unknown Source Infections

Bone and Joint Infections Infective Endocarditis

Dose (based on actual body weight)

 <50 kg  400mg  600mg 600mg 
 50 - 74 kg  600mg  800mg  800mg
 75 - 100kg 800mg 1000mg 1000mg
 >100kg  1000mg  1200mg  1200mg
 Frequency  12 hourly  12 hourly 12 hourly 
 Duration  4 doses  4 doses  5 doses
 Frequency  Once a day  Once a day  Once a day
 Starting  24 hours after loading  24 hours after loading  24 hours after loading
 Levels (trough - prior to dose)   
 When  Day 5  Day 5  Day 5
 Target range  15-60mg/L  20-60mg/L  30-60mg/L
 Repeat  Weekly unless advised otherwise   Weekly unless advised otherwise   Weekly unless advised otherwise


Main indications:

  • Community Acquired Pneumonia if suspected/confirmed MRSA
  • Cellulitis if suspected/confirmed MRSA
  • Chronic diabetic ulcers if suspected/confirmed MRSA
  • Infection of unknown site if past history of MRSA

Active against most strains of:

  • Staphylococcus aureus – including MRSA
  • Staphylococcus epidermidis
  • Streptococcus spp
  • Enterococcus faecalis

Not active against most strains of:

  • Haemophilus influenzae
  • Escherichia coli
  • Coliforms
  • Pseudomonas

Last Reviewed: 18/02/17