Please note: This is for information only.
Refer to local guidelines for treatment recommendations
- A glycopeptide antibiotic (closely related to teicoplanin).
- Usual adult dose 1g BD IV but dose must be reduced in elderly patients or patients with renal impairment.
- IV Vancomycin therapy requires monitoring of serum levels to ensure efficacy and minimise toxicity. IV Vancomycin must be given by slow IV infusion over at least 2 hours.
- Oral vancomycin is NOT absorbed and cannot be used for systemic infections. It is a 2nd-line treatment for Clostridium difficile associated diarrhoea (125 mg PO QDS).
- Severe community-acquired pneumonia (in patients with a risk of MRSA)
- 1st line therapy for suspected staphylococcal sepsis in patients with a risk of MRSA.
- C.difficile infection
Active against most strains of:
- Staphylococcus aureus (including MRSA)
- Clostridium difficile
- Clostridium perfringens
Not active against:
- Vancomycin-resistant Entercocci
- Vancomycin resistant enterococci (VRE) - becoming more prevalent due to widespread vancomycin use
- A few strains of Staphylococcus aureus (GISA) and Staph.epidermidis are now vancomycin insensitive.