Uncomplicated Gonococcal Infection - Antibiotic Management

Both locally and nationally, resistance in gonococcal isolates has meant that both the penicillin and quinolone antibiotics can no longer be relied upon for empirical treatment of gonococcal disease. Intramuscular ceftriaxone is now the standard treatment for infections where sensitivity results are unknown.


1st line:

Ceftriaxone 250mg IM stat

if known ciprofloxacin sensitive strain and not pregnant or breastfeeding:

Ciprofloxacin 500mg orally stat.


Adjust antibiotics according to culture and sensitivity results only if no improvement, and after discussion with microbiology (in view of rising resistance in gonococcal isolates).