Amphotericin: Dose adjustment for renal impairment
- Dosing recommendations are based on creatinine clearance calculated using the Cockcroft-Gault equation.
- Do not use eGFR estimates (available on PAS) for drug dosing purposes (for more information click here )
- To calculate creatinine clearance (CrCl) using the Cockcroft-Gault equation, use the creatinine clearance calculator :
- Accurate estimation of CrCl is only possible in patients with STABLE renal function. In patients with rapidly changing renal function (i.e. ACUTE renal failure), the serum creatinine levels will no longer provide a true reflection of renal function.
- Dose adjustment may not be appropriate in ACUTE renal impairment secondary to SEPSIS. In this case it is important to treat the infection aggressively for the first 24hrs and re-check renal function before reducing the dose accordingly.
- (In 'acute on chronic' renal impairment the initial dose should correspond to the previous level of chronic renal impairment).
- Amphotericin is highly NEPHROTOXIC - Daily monitoring of renal function is essential
- Consider using liposomal amphotericin (Ambisome®) for patients with impaired renal function. For those without renal impairment, use conventional amphotericin (Fungizone®). See antifungal policy (click here)
- Important: Amphotericin must be prescribed by brand name i.e. Fungizone or Ambisome
Dose adjustment for renal impairment: