Teicoplanin: Dose adjustment for renal impairment

  • Dosing recommendations are based on creatinine clearance calculated using the Cockcroft-Gault equation.
  • Do not use eGFR estimates (available on PAS) for drug dosing purposes (for more information  click here )
  • To calculate creatinine clearance (CrCl) using the Cockcroft-Gault equation, use the creatinine clearance calculator :
  • Accurate estimation of CrCl is only possible in patients with STABLE renal function. In patients with rapidly changing renal function (i.e. ACUTE renal failure), the serum creatinine levels will no longer provide a true reflection of renal function.
  • Dose adjustment may not be appropriate in ACUTE renal impairment secondary to SEPSIS. In this case it is important to treat the infection aggressively for the first 24hrs and re-check renal function before reducing the dose accordingly.
  • (In 'acute on chronic' renal impairment the initial dose should correspond to the previous level of chronic renal impairment).
CrCl (ml/min) Dose
Greater than 30

Normal loading and maintenance dosing

Less than or equal to 30

Normal loading and maintenance dosing up to and including day 4. The original dose should then be continued every 72 hours.

The information above is based on the summary of product characteristics.  

Example prescription (including loading and maintenance doses)

Mr B weighs 80kg and has an infection of his right hip. He has a CrCl of 20ml/min.

 Teicoplanin prescription

For advice on teicoplanin dosing if CrCl greater than 30ml/min(click here).

Refer to Renal Pharmacist or Medicines Information for advice on dosing in haemodialysis and peritoneal dialysis.

Last Reviewed: 18/3/14