Unknown Infection Site

Likely Community Acquired, No Risk Factors for MRSA or ESBL Producing Organisms

 

Severity
(classification)

1st line oral/iv antibiotics

Penicillin allergy
(see explanatory notes)

A/B/C

Grading not applicable

Review doses in renal impairment

BENZYLPENICILLIN 2.4g iv qds or every 4 hours depending on severity
plus
FLUCLOXACILLIN 1g iv qds
plus
GENTAMICIN iv (as per local protocol)

Review use of gentamicin within 72 hours with culture results and consider alternative therapy.  Note that duration of gentamicin treatment should not normally exceed 7 days.

 

 

 

 

 

 

 

 

Review initial therapy within 24 hrs.
If a source of infection becomes apparent use the appropriate antibiotic guideline. Modify the rapy based on results of microbiological or other investigations. Discuss with microbiologist if required.

 

 

 

 

TEICOPLANIN iv every 12 hours for 4 doses then once daily.

Dose

<50kg: 400mg

50-74kg: 600mg

75-100kg: 800mg

>100kg: 1000mg 

Maintain treatment pending pre-dose (trough) level on Day 5. Target level 15-60mg/L. (Click for dosing table)

plus

GENTAMICIN iv (as per local protocol)

Review use of gentamicin within 72 hours with culture results and consider alternative therapy.  Note that duration of gentamicin treatment should not normally exceed 7 days.

 

Review initial therapy within 24 hrs.
If a source of infection becomes apparent use the appropriate antibiotic guideline. Modify the rapy based on results of microbiological or other investigations. Discuss with microbiologist if required

 

 

.

 

 

Last reviewed: 18/01/2017 

For guidance on the administration of intravenous antibiotics click here
(GHNHSFT intranet)