Autoimmune neutropenia

Autoimmune neutropenia (AIN) is a rare clinical condition caused by granulocyte autoantibodies, which may occur either in children or adults, but which often remains undiagnosed. AIN commonly occurs in children between the ages of 6 months and 5 years. Autoimmune Neutropenia in Infancy tends to be a self-limiting autoimmune condition but can last several years. In adults, AIN presents as a chronic disorder either as an isolated (primary) neutropenia or as a neutropenia secondary to other disorders, such as rheumatoid arthritis, systemic lupus erythematosus, Felty's syndrome and chronic lymphocytic and large granulocyte leukaemias.

Blood Transfusion

Notes

• Requires Consultant Haematologist approval
• Neutrophil count of patient should be <2.0
• Histocompatibility & Immunogenetics Granulocyte Immunology 3E required to request this test (form available from Transfusion laboratory or available using the link below)
• Performed at NHSBT, Bristol, Filton

H&I Request Form (3E) - Granulocyte Immunology

Sample requirements

Adult

Serum tube - 6mL

Infant

2 mL EDTA tube

Paediatric serum tube

Required information

Sample and request form must be labelled correctly with 4 points of reference:

1. Forename
2. Surname
3. Date of birth
4. NHS No.

The sample tube(s) must be signed and dated by the person taking the blood.

The NHSBT may decline to test inadequately labelled samples.

For further information on specimen labelling refer to the H&I 3E Platelet Immunology request form

Turnaround time

Up to 21 working days