Beta 2 Glycoprotein 1 Antibodies IgG and IgM (B2GP1)

Department of Immunology

Notes

• Beta-2-Glycoprotein 1 is one of the major targets for anti-phospholipid antibodies. Anti-B2GP1 antibodies are associated with antiphospholipid syndrome, where patients suffer from venous and arterial thrombosis particularly in recurrent unexplained thrombocytopenia, recurrent foetal loss, myocardial infarction and recurrent stroke.
• The measurement of beta-2-glycoprotein antibodies is of most use in patients suspected of having antiphospholipid syndrome who have negative results for lupus anticoagulant and anti-cardiolipin antibodies. It is recommended that positive results are confirmed after 12 weeks.
• Test performed at PRU, Northern General Hospital, Sheffield.
  

Sample Requirements

Clotted blood. (No patient preparation or special handling required)

Adult

5ml Gold-top SST tube or 3.5ml Rust-top gel tube (Trust users only)

Paediatric

1ml serum Sample

Time limit for add-on

3 days

Turnaround Times

21 days

Reference Range

IgG and IgM B2GP

0 - 10 U/mL Negative

> 10.0 U/mL Positive