IgG Subclasses
Department of Immunology
Notes
- Useful in the diagnosis of primary antibody deficiency syndromes.
- The use of this test is based on clinical guidelines.
- This test can identify individuals with extremely low or absent IgG2 concentrations, demonstrating an inability to produce antibodies against polysaccharide antigens.
- Completely asymptomatic individuals who totally lack IgG1, IgG2, IgG4 or IgA1 class immunoglobulins because of heavy chain deletions have been shown to produce antibodies against the antibody class they lack (eg. IgA1 deficient patients may develop anti-IgA1 antibodies).
Sample Requirements
Adult
5ml Gold-top SST tube or 3.5ml Rust-top gel tube (Trust users only)
Paediatric
1ml Serum Sample
Turnaround Times
2 weeks